Background: This study provides descriptive epidemiological data of invasive lung and bronchus cancer diagnosed from 1999 to 2014 in the United States of America.
Methods: This is a retrospective descriptive epidemiological analysis of invasive lung and bronchus cancer recorded in the Centres for Disease Control and Prevention from 1999 to 2014. The statistical analyses were performed using descriptive statistics to calculate the overall age-adjusted incidence rate stratified by state, race, and gender.
 Results: The state of Kentucky, West Virginia, Missouri, Indiana, Detroit, and Maine had the highest overall age-adjusted incidence rate of invasive lung and bronchus cancer among males and females White American, from 1999 to 2014. The state of Kentucky, Wisconsin, Iowa, Nebraska, and Pennsylvania had the highest overall age-adjusted incidence rate of invasive lung and bronchus cancer among males and females Black American, from 1999 to 2014. While, the state of Hawaii, Detroit, and Connecticut had the highest overall ageadjusted incidence rate of invasive lung and bronchus cancer among males and females Hispanic American, from 1999 to 2014. Conclusion: This study revealed that the state of Kentucky, West Virginia, Missouri, Indiana, Detroit, and Maine are the best geographic areas in the United States of America, for studying the most important risk factors of invasive lung and bronchus cancer among males and females White American. While, the states of Kentucky, Wisconsin, Iowa, Nebraska, and Pennsylvania are the best geographic areas for males and females Black American. In addition, the state of Connecticut, Detroit, and Hawaii, are the best geographic areas for studying the most important risk factors of invasive lung and bronchus cancer among males and females Hispanic American. However, the secret for confirming the real risk factor for lung and bronchus cancer can be found among males and females Hispanic American living in the state of Hawaii. Therefore, multiple case-control studies adjusted by race and gender should be conducted in the mentioned states to identify the major risk factors that can be controlled.